Spero Therapeutics

Associate Director, Program Management

Job Locations US-MA-Cambridge | US
150 R&D Management
Position Type
Regular Full-Time

About Us

Spero Therapeutics (Nasdaq: SPRO) is a multi-asset pre-commercial stage biopharmaceutical company in Cambridge, Mass. We are highly committed to advancing novel treatment approaches for bacterial infections with a world-class team of biotech and drug development experts. The company has a pipeline of novel and highly differentiated antibacterial and rare disease product candidates focused on patients with unmet need associated with multi-drug resistant (MDR) bacterial infections. Spero’s lead product candidate, SPR720, is an oral antimicrobial agent in development for the treatment of nontuberculous mycobacterial (NTM) pulmonary disease, a rare orphan disease.  Spero’s partnership directed programs consist of SPR206 and tebipenem HBr. SPR206, is an IV-administered agent being developed as an innovative option to treat MDR Gram-negative bacterial infections and tebipenem HBr, is an oral carbapenem being developed as the first oral carbapenem antibiotic for use in complicated urinary tract infections (cUTI) and acute pyelonephritis (AP). In September 2022, Spero announced an exclusive license agreement with GSK for worldwide rights of tebipenem HBr, except for Japan and certain Asian countries.
We believe that our novel product candidates will have a meaningful impact on patient health and significant commercial applications for treating MDR infections in hospitals and community settings.



Spero Therapeutics is looking for a collaborative, enthusiastic Program Manager. This individual will work closely with the Program Team Lead and the cross-functional program team to convert strategic objectives into operational project plans and to meet the goals/timelines for those projects. This role offers the opportunity to be an integral part of the Spero team by contributing to key programs in the company’s portfolio.


What you'll do


  • Create detailed cross-functional, cross-project project plan and dashboards to track and communicate progress at a level of detail and in a format consistent with Spero standards to the appropriate stakeholders. 

  • Partner with the Program Team Lead and cross-functional team to manage multiple, complex activities across multiple functions (including research, pharmacology, toxicology, manufacturing, regulatory and clinical) to execute on the development plan.

  • Run cross functional team meetings as well as key sub-team meetings and ensure that clear agendas are set, and actions and decisions are documented, communicated, and committed to, enabling timeline achievement.

  • Ensure effective communication of project deliverables up and across the organization.

  • Identify continuous improvement and lessons learned opportunities to the team.

  • Utilize effective communication skills to promote timely and appropriate information exchange between Functional Lines, Development Program Leader, Core Team, and senior management.

  • Work with the Program Core Team to proactively identify risks and issues and pavoid/mitigate them.

  • Work with the Program Team Lead and Core Team members to set program strategy and objectives, key milestones, and scope in accordance with corporate objectives.

  • Work with the Program Team Lead, to liaise with finance to ensure alignment between program goals and financial forecast.

  • Manage collaboration and sharing of information on MS Teams and SharePoint sites.

What you'll need

  • BS in life sciences or related field required; MS in life sciences or MBA preferred.
  • Minimum 5 years multi-disciplinary knowledge of the biopharmaceutical industry required.
  • Minimum 3 years of direct project management experience required.
  • A thorough understanding of the drug development process and working knowledge of the essential activities for all key functional areas.
  • Demonstrated experience in managing complex projects and working successfully in a diverse team.
  • Demonstrated success comprehending and communicating the big picture while also identifying and managing the details.
  • Proven ability to coordinate cross-functional projects to achieve milestones and deliverables on schedule.
  • Proven ability to work collaboratively and influence without direct authority.
  • Strong team player that has a customer service approach and is solution oriented.
  • Strong analytical and technical skills, including proficiency in project management practices, project planning, and decision-making. 
  • Skilled with Microsoft Office Suite and Microsoft Project.
  • Excellent written and presentation skills, and information management skills.

By joining our committed and highly motivated team, you’ll experience a workplace culture that is inclusive, fair, challenging, supportive, and respectful. Spero’s culture is one that emphasizes “servant leadership,” or putting ego aside and working for the benefit of the team and our patients, and values our colleagues’ opinions and celebrates accomplishments in service of patients. Spero provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws. Spero requires all employees to be vaccinated against COVID-19 absent a bona fide medical reason or genuine religious belief relating to vaccinations. All employees must be in compliance with Spero Therapeutics’ COVID-19 vaccine policy at the time of employment.


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